Do certain frame or nose pad materials irritate your skin? Tell your eye doctor or optician, who can help you find eyeglasses you can wear comfortably. Here's the lowdown on materials: If metal frames cause a reaction, nickel is usually the culprit because most metal frames are made of a nickel alloy. Other metals used include aluminum, stainless steel, titanium, zinc, copper, beryllium, gold and silver. Stainless, titanium, gold and silver are usually hypoallergenic. Some people are allergic to the nose pads on metal frames. Most are made of silicone or acetate, but they also can be made of polyvinyl chloride (PVC), nickel, titanium or rubber. Silicone is tricky: certain silicones are hypoallergenic (such as medical silicone), but others can trigger allergic reactions. Both PVC and titanium are usually hypoallergenic. Most plastic glasses are made of zyl (also called zylonite, acetate and cellulose acetate) or propionate. Other materials used in plastic frames include polyamide, nylon, polycarbonate, carbon and Optyl (a brand of epoxy resin). Propionate, polyamide, nylon and Optyl frames are all considered hypoallergenic.